Fore Biotherapeutics

Philadelphia, PA Biotechnology Private

Fore Biotherapeutics is a Philadelphia-based registration-stage precision oncology company developing targeted therapies for patients with cancers driven by BRAF mutations. Its lead asset, plixorafenib (FORE8394; formerly PLX8394), is a novel, orally available small-molecule selective BRAF inhibitor and 'paradox breaker' rationally designed to address both V600 and non-V600 BRAF alterations while avoiding the paradoxical MAPK pathway activation seen with first-generation BRAF inhibitors. Plixorafenib is being evaluated in the global Phase 2 FORTE Master Protocol across three monotherapy indications: BRAF V600 recurrent primary CNS tumors, rare BRAF V600 mutated solid tumors, and advanced solid tumors with BRAF fusions. The FDA has granted Breakthrough Therapy Designation to plixorafenib for adult patients with BRAF V600E-mutated high-grade glioma. The company was originally founded as functional-genomics diagnostics startup NovellusDx and pivoted to precision oncology, establishing Fore Biotherapeutics as its U.S. operating company in 2021.

Overview

Company data and valuation marks are estimates and may be incomplete, stale, erroneous, or revised.

Founded

2011

Employees

40–60

Total Funding

$190.5M

6 rounds

Funding

Total raised $190.5M across 6 rounds

Funding data and valuation marks are estimates and may be incomplete, stale, erroneous, or revised.

Last updated 06-25-2026

Latest Round

Type

Series D-2

Date

May 22, 2025

Amount

$38M

Valuation

Lead Investors

OrbiMed
DateRoundAmount RaisedValuationLead Investors
May 22, 2025 Series D-2 $38M OrbiMed
August 23, 2023 Series D $75M SR One
September 2020 Series C $57M Pontifax

Leadership

  • William Hinshaw

    Chief Executive Officer and Member of the Board of Directors

  • Stacie Peacock Shepherd

    Chief Medical Officer

  • Michael Byrnes

    Chief Financial Officer

  • Payman Darouian

    Senior Vice President, Corporate Development, Strategy and Commercial

  • Dieter Weinand

    Chairman of the Board

Competitors

Competitor list is illustrative and may be incomplete, stale, or erroneous.

  • Day One Biopharmaceuticals

    Public oncology company whose Type II RAF inhibitor tovorafenib (OJEMDA) received FDA accelerated approval for relapsed/refractory pediatric low-grade glioma with BRAF fusions or V600 mutations, directly overlapping with plixorafenib's CNS and BRAF-fusion target indications.

  • Novartis

    Pharma incumbent marketing Tafinlar (dabrafenib) plus Mekinist (trametinib), the standard-of-care BRAF/MEK combo for V600-mutated tumors including melanoma, NSCLC and certain gliomas; the regimen plixorafenib is designed to displace or compete with in non-V600 and CNS settings.

  • BeiGene

    Global oncology company developing lifirafenib (BGB-283), a RAF dimer inhibitor active against both BRAF V600 and select non-V600 mutations, positioning it as a direct mechanistic competitor to plixorafenib.

  • Pfizer (Array BioPharma)

    Markets Braftovi (encorafenib), an FDA-approved BRAF V600 inhibitor used in combination regimens for melanoma and BRAF V600E metastatic colorectal cancer; an established competitor in the V600 BRAF inhibitor landscape.

  • Erasca

    Clinical-stage precision oncology company developing a pipeline of RAS/MAPK pathway inhibitors, including pan-RAF and pan-KRAS programs, competing for the same BRAF/RAS-driven tumor patient populations targeted by plixorafenib.

  • Takeda Pharmaceutical

    Large pharma developing exarafenib and other pan-RAF inhibitors as treatments for glioma and BRAF-altered solid tumors, overlapping mechanistically with plixorafenib's paradox-breaker positioning.

Fore Biotherapeutics Investment FAQ

Public status and buying access

No. Fore Biotherapeutics is a private company and does not have a public stock ticker or trade on a public stock exchange. Its shares are generally held by founders, employees, investors, and other private shareholders. Buyers and sellers may be able to transact in Fore Biotherapeutics shares through private secondary transactions, but any transaction depends on share availability, buyer and seller agreement, transfer restrictions, company approval rights, and any applicable right of first refusal. There is no guarantee that Fore Biotherapeutics will complete an IPO or other liquidity event.

Yes, it is sometimes possible to buy Fore Biotherapeutics shares pre-IPO through private secondary transactions. This depends on finding a willing seller, company approval, and satisfying any transfer restrictions or rights of first refusal.

Buyers interested in buying Fore Biotherapeutics shares on the secondary market typically do so through SetterVC and other secondary-market platforms, subject to eligibility requirements, share availability, transfer restrictions, and issuer approval. Buyers may need to satisfy sophistication, accreditation, institutional, platform, regulatory, or other eligibility requirements before participating. Once eligible, buyers may be able to view listings, make bids, and work with a licensed broker through the transaction process. Buyers should ensure they have appropriate legal and financial advisors guiding them before completing any transaction.

Valuation and funding

Fore Biotherapeutics's latest disclosed funding round was a Series D-2 round in May 22, 2025. The round raised approximately $38M, with OrbiMed listed as disclosed lead or major investors. Primary funding rounds are different from secondary transactions: in a primary round, capital goes to the company, while in a secondary transaction, investors buy existing shares from current shareholders. Funding-round data reflects publicly reported or collected information and may be incomplete.

Fore Biotherapeutics has raised approximately $190.5M in disclosed funding across 6 rounds. These figures reflect primary capital raised by the company and do not include every possible secondary transaction, undisclosed round, debt facility, or private transfer. Reported funding totals can change as new rounds are announced or older round details are corrected. Eligible users can use SetterVC to track Fore Biotherapeutics's funding history alongside private-market activity where available.

Fore Biotherapeutics's disclosed investors include OrbiMed, SR One, Pontifax and IntraCure. Investor lists are based on public reporting, company announcements, and collected funding-round data, and may be incomplete. Participation in a prior funding round does not mean those investors are currently buying or selling shares. On SetterVC, eligible users can review Fore Biotherapeutics's funding history, valuation history, and private-market activity alongside other venture-backed companies.

Market context

Fore Biotherapeutics's most-cited competitors include Day One Biopharmaceuticals, Novartis, BeiGene, Pfizer (Array BioPharma), Erasca and Takeda Pharmaceutical. Investors often compare these companies by sector, product focus, valuation, funding raised, growth signals, investor base, and private-market activity.

Secondary-market demand for Fore Biotherapeutics shares can be affected by company performance, revenue growth, profitability, funding history, valuation, investor interest, sector momentum, public-market conditions, expected timing of a liquidity event, and the availability of shares for sale. Demand can also be affected by transfer restrictions, company approval rights, right of first refusal processes, limited information, and the price expectations of buyers and sellers. Strong demand does not guarantee strong pricing, liquidity, or investment returns. Weak demand does not necessarily reflect the company's long-term prospects. Demand signals should not be treated as a recommendation or prediction of investment performance. Buyers and sellers should treat demand signals as informational and conduct their own diligence before transacting.

Selling and transaction mechanics

Sellers often rely on intermediaries and platforms, such as SetterVC and other secondary-market platforms, to identify potential buyers. The exact process varies by company and transaction, but sellers often begin by confirming their ownership, desired price, transferability, and any company approval or notice requirements. If the seller agrees with a buyer on acceptable price and terms, the company may need to be notified through a share transfer notice or similar process. If a right of first refusal, company approval right, or other transfer restriction applies, the seller may need to wait until that process is completed. The parties may then execute a purchase and sale agreement, complete required transfer documentation, and close if all required conditions are satisfied. Sellers should always seek proper legal and financial advice before completing the transaction.

Yes, current and former Fore Biotherapeutics employees, early investors, and other existing shareholders may be able to sell vested shares before an IPO through a private secondary sale. This is not automatic; it depends on whether the shareholder has transferable shares, whether there is buyer demand, and whether the company's governing documents permit the transfer. Many companies require prior notice, company approval, or a right of first refusal before shares can be sold. Sellers should also seek proper legal and financial advice before proceeding.

A Fore Biotherapeutics secondary transaction usually involves an existing shareholder selling shares to a buyer before a public listing. The buyer and seller typically agree on price, number of shares, share class, and closing conditions. The seller may then need to notify Fore Biotherapeutics through a share transfer notice or similar process. If Fore Biotherapeutics or existing investors have approval rights, transfer restrictions, or a right of first refusal, those steps may need to be completed before the transfer can close. The parties typically enter into a purchase and sale agreement, complete any required transfer documentation, and close only if the necessary conditions are satisfied. Timing and certainty can vary by company and transaction.

In most private secondary transactions, parties commonly use a purchase and sale agreement that outlines price, terms, and conditions. They may also use share transfer documentation, often a stock transfer notice, share transfer notice, transfer instruction, or similar document, along with any required company approval or right of first refusal materials. Proof of ownership, such as a cap table entry, share certificate, brokerage statement, issuer confirmation, or administrator confirmation, may also be important. Buyers often request recent company financials, but private companies may limit disclosure. Since every deal varies, buyers and sellers should consult legal and financial advisors to understand which documents are needed.

Risk, diligence, and investor caution

Buying Fore Biotherapeutics shares pre-IPO is risky. Shares are illiquid, no IPO or liquidity event is guaranteed, valuations can change, transfers may require company approval, and private companies may provide limited financial disclosure. Be prepared for total loss. SetterVC and Setter Capital do not provide due diligence, legal, tax, accounting, valuation, or investment advice. Buyers must conduct their own due diligence, verify information, and seek independent legal and investment advice before proceeding.

Private secondary shares are typically illiquid. Unlike public stocks, there is no active public market, so selling them can be difficult and time-consuming. Sales depend on finding a willing buyer and often require company approval. Investors should be prepared to hold the shares for an extended period, with no guarantee of a future sale. Always assess your need for liquidity before investing.

SetterVC and Setter Capital do not provide due diligence, legal, tax, accounting, valuation, or investment advice. Buyers must conduct their own due diligence, including verifying ownership, transferability, legal structure, company approval, and assessing the company's prospects. SetterVC and Setter Capital do not provide advice on whether an investment is good, what price to pay, or what the best bid or ask is. SetterVC and Setter Capital may share documents in some circumstances, but it does not guarantee their accuracy or completeness. Due diligence is essential. Seek legal and investment advice as needed.

Before buying Fore Biotherapeutics shares, a buyer should try to review the share class, price per share, implied valuation, transfer restrictions, ROFR process, company approval rights, seller ownership evidence, recent financing or tender-offer information, available financial information, information rights, resale restrictions, tax considerations, and expected liquidity paths. Not all information may be available for a private company. Buyers should confirm available diligence, process details, and information needs with their own legal, tax, and investment advisers.

SPVs carry risks. Examples include the need to confirm the company allows SPV-based transfers, verify that the SPV truly owns the shares or interests it claims to own, and ensure it has not sold more interests than it holds. Due diligence is essential. Seek legal and investment advice as needed.

Forward contracts carry risks. Examples include the seller refusing to transfer the shares at the future date, even if the seller owns them, the seller going bankrupt with creditors claiming the shares, or the seller committing the same shares to multiple parties. Due diligence is essential. Seek legal and investment advice as needed.

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