
Frontier Medicines is a precision oncology biotechnology company that has built a discovery and development platform combining chemoproteomics, covalent drug discovery, and machine learning to develop small-molecule therapeutics against historically undruggable disease-driving proteins. Its lead clinical-stage program, FMC-376, is a dual ON+OFF KRAS G12C inhibitor designed to overcome resistance seen with first-generation single-state inhibitors and is being evaluated in the Phase 1/2 PROSPER trial (NCT06244771) across KRAS G12C-mutant solid tumors including non-small cell lung, colorectal, and pancreatic cancers. The company maintains a wholly-owned pipeline spanning multiple precision oncology targets and is headquartered in South San Francisco with a presence in Boston.
Company data and valuation marks are estimates and may be incomplete, stale, erroneous, or revised.
Founded
2018
Employees
50–100
Total Funding
$255.5M
4 rounds
Latest Valuation
$0.25B
June 25, 2024
Total raised $255.5M across 4 rounds
Funding data and valuation marks are estimates and may be incomplete, stale, erroneous, or revised.
Last updated 06-25-2026
Latest Round
Type
Series A
Date
June 25, 2019
Amount
$67M
Valuation
$0.25B
Lead Investors
| Date | Round | Amount Raised | Valuation | Lead Investors |
|---|---|---|---|---|
| June 25, 2024 | Series C-II (extension) | $20M | — | Not disclosed |
| February 15, 2024 | Series C | $80M | — | Deerfield Management, Droia Ventures |
| July 15, 2021 | Series B | $88.5M | — | Woodline Partners, RA Capital Management |
Competitor list is illustrative and may be incomplete, stale, or erroneous.
Revolution Medicines
Public clinical-stage oncology company developing RAS(ON) inhibitors including RMC-6236 and the KRAS G12C(ON) inhibitor RMC-6291; the most direct competitor on dual-state KRAS targeting.
Amgen
Marketer of Lumakras (sotorasib), the first FDA-approved KRAS G12C(OFF) inhibitor; incumbent commercial benchmark Frontier's FMC-376 aims to displace.
Bristol Myers Squibb (Mirati Therapeutics)
Owns Krazati (adagrasib), the second FDA-approved KRAS G12C(OFF) inhibitor, acquired via the 2024 Mirati buyout; another direct KRAS G12C commercial competitor.
Quanta Therapeutics
Private precision oncology biotech also developing allosteric KRAS inhibitors and additional MAPK pathway targets, competing in the next-wave KRAS landscape.
Verastem Oncology
Public oncology company with RAS/MAPK pathway combinations (avutometinib + defactinib) targeting overlapping KRAS-mutant tumor populations.
Eli Lilly
Large pharma with internal KRAS G12C and pan-KRAS inhibitor programs in early clinical development, representing well-capitalized competition for next-generation KRAS therapies.
No. Frontier Medicines is a private company and does not have a public stock ticker or trade on a public stock exchange. Its shares are generally held by founders, employees, investors, and other private shareholders. Buyers and sellers may be able to transact in Frontier Medicines shares through private secondary transactions, but any transaction depends on share availability, buyer and seller agreement, transfer restrictions, company approval rights, and any applicable right of first refusal. There is no guarantee that Frontier Medicines will complete an IPO or other liquidity event.
Yes, it is sometimes possible to buy Frontier Medicines shares pre-IPO through private secondary transactions. This depends on finding a willing seller, company approval, and satisfying any transfer restrictions or rights of first refusal.
Buyers interested in buying Frontier Medicines shares on the secondary market typically do so through SetterVC and other secondary-market platforms, subject to eligibility requirements, share availability, transfer restrictions, and issuer approval. Buyers may need to satisfy sophistication, accreditation, institutional, platform, regulatory, or other eligibility requirements before participating. Once eligible, buyers may be able to view listings, make bids, and work with a licensed broker through the transaction process. Buyers should ensure they have appropriate legal and financial advisors guiding them before completing any transaction.
The company's latest round valuation was approximately $250M as of June 25, 2024. The latest round valuation is often used as one reference point in secondary-market pricing, but secondary prices may be above or below that valuation at any given time. Secondary pricing can shift significantly based on post-round conditions, such as changes in company performance, supply-demand dynamics, share class, transaction size, transfer restrictions, or broader market shifts. Any implied valuation from a past round should be confirmed with a broker or through live market listings before relying on it.
Frontier Medicines was most recently valued at approximately $250M as of June 25, 2024. This is a private valuation and may differ from secondary pricing. Secondary shares may trade above or below this mark based on various factors. SetterVC and Setter Capital does not verify the accuracy of these valuations. Buyers and sellers should always confirm current valuations before completing any transaction.
SetterVC currently shows one valuation mark for Frontier Medicines based on funding rounds, tender offers, secondary-market indications, and other reported or collected valuation marks. Frontier Medicines's valuation was approximately $250M as of June 25, 2019. Secondary-market prices may differ from this valuation based on share class, transaction size, transfer restrictions, supply and demand, company performance, and broader market conditions. SetterVC and Setter Capital does not verify the accuracy or completeness of valuation data, and buyers and sellers should confirm current information before relying on it.
Frontier Medicines's latest disclosed funding round was a Series C-II (extension) round in June 25, 2024. The round raised approximately $20M. Primary funding rounds are different from secondary transactions: in a primary round, capital goes to the company, while in a secondary transaction, investors buy existing shares from current shareholders. Funding-round data reflects publicly reported or collected information and may be incomplete.
Frontier Medicines has raised approximately $255.5M in disclosed funding across 4 rounds. These figures reflect primary capital raised by the company and do not include every possible secondary transaction, undisclosed round, debt facility, or private transfer. Reported funding totals can change as new rounds are announced or older round details are corrected. Eligible users can use SetterVC to track Frontier Medicines's funding history alongside private-market activity where available.
Frontier Medicines's disclosed investors include Droia Ventures, Galapagos, DCVC Bio, MPM Capital, RA Capital Management and Deerfield Management. Investor lists are based on public reporting, company announcements, and collected funding-round data, and may be incomplete. Participation in a prior funding round does not mean those investors are currently buying or selling shares. On SetterVC, eligible users can review Frontier Medicines's funding history, valuation history, and private-market activity alongside other venture-backed companies.
Frontier Medicines's most-cited competitors include Revolution Medicines, Amgen, Bristol Myers Squibb (Mirati Therapeutics), Quanta Therapeutics, Verastem Oncology and Eli Lilly. Investors often compare these companies by sector, product focus, valuation, funding raised, growth signals, investor base, and private-market activity.
Secondary-market demand for Frontier Medicines shares can be affected by company performance, revenue growth, profitability, funding history, valuation, investor interest, sector momentum, public-market conditions, expected timing of a liquidity event, and the availability of shares for sale. Demand can also be affected by transfer restrictions, company approval rights, right of first refusal processes, limited information, and the price expectations of buyers and sellers. Strong demand does not guarantee strong pricing, liquidity, or investment returns. Weak demand does not necessarily reflect the company's long-term prospects. Demand signals should not be treated as a recommendation or prediction of investment performance. Buyers and sellers should treat demand signals as informational and conduct their own diligence before transacting.
Sellers often rely on intermediaries and platforms, such as SetterVC and other secondary-market platforms, to identify potential buyers. The exact process varies by company and transaction, but sellers often begin by confirming their ownership, desired price, transferability, and any company approval or notice requirements. If the seller agrees with a buyer on acceptable price and terms, the company may need to be notified through a share transfer notice or similar process. If a right of first refusal, company approval right, or other transfer restriction applies, the seller may need to wait until that process is completed. The parties may then execute a purchase and sale agreement, complete required transfer documentation, and close if all required conditions are satisfied. Sellers should always seek proper legal and financial advice before completing the transaction.
Yes, current and former Frontier Medicines employees, early investors, and other existing shareholders may be able to sell vested shares before an IPO through a private secondary sale. This is not automatic; it depends on whether the shareholder has transferable shares, whether there is buyer demand, and whether the company's governing documents permit the transfer. Many companies require prior notice, company approval, or a right of first refusal before shares can be sold. Sellers should also seek proper legal and financial advice before proceeding.
A Frontier Medicines secondary transaction usually involves an existing shareholder selling shares to a buyer before a public listing. The buyer and seller typically agree on price, number of shares, share class, and closing conditions. The seller may then need to notify Frontier Medicines through a share transfer notice or similar process. If Frontier Medicines or existing investors have approval rights, transfer restrictions, or a right of first refusal, those steps may need to be completed before the transfer can close. The parties typically enter into a purchase and sale agreement, complete any required transfer documentation, and close only if the necessary conditions are satisfied. Timing and certainty can vary by company and transaction.
In most private secondary transactions, parties commonly use a purchase and sale agreement that outlines price, terms, and conditions. They may also use share transfer documentation, often a stock transfer notice, share transfer notice, transfer instruction, or similar document, along with any required company approval or right of first refusal materials. Proof of ownership, such as a cap table entry, share certificate, brokerage statement, issuer confirmation, or administrator confirmation, may also be important. Buyers often request recent company financials, but private companies may limit disclosure. Since every deal varies, buyers and sellers should consult legal and financial advisors to understand which documents are needed.
Buying Frontier Medicines shares pre-IPO is risky. Shares are illiquid, no IPO or liquidity event is guaranteed, valuations can change, transfers may require company approval, and private companies may provide limited financial disclosure. Be prepared for total loss. SetterVC and Setter Capital do not provide due diligence, legal, tax, accounting, valuation, or investment advice. Buyers must conduct their own due diligence, verify information, and seek independent legal and investment advice before proceeding.
Private secondary shares are typically illiquid. Unlike public stocks, there is no active public market, so selling them can be difficult and time-consuming. Sales depend on finding a willing buyer and often require company approval. Investors should be prepared to hold the shares for an extended period, with no guarantee of a future sale. Always assess your need for liquidity before investing.
SetterVC and Setter Capital do not provide due diligence, legal, tax, accounting, valuation, or investment advice. Buyers must conduct their own due diligence, including verifying ownership, transferability, legal structure, company approval, and assessing the company's prospects. SetterVC and Setter Capital do not provide advice on whether an investment is good, what price to pay, or what the best bid or ask is. SetterVC and Setter Capital may share documents in some circumstances, but it does not guarantee their accuracy or completeness. Due diligence is essential. Seek legal and investment advice as needed.
Before buying Frontier Medicines shares, a buyer should try to review the share class, price per share, implied valuation, transfer restrictions, ROFR process, company approval rights, seller ownership evidence, recent financing or tender-offer information, available financial information, information rights, resale restrictions, tax considerations, and expected liquidity paths. Not all information may be available for a private company. Buyers should confirm available diligence, process details, and information needs with their own legal, tax, and investment advisers.
SPVs carry risks. Examples include the need to confirm the company allows SPV-based transfers, verify that the SPV truly owns the shares or interests it claims to own, and ensure it has not sold more interests than it holds. Due diligence is essential. Seek legal and investment advice as needed.
Forward contracts carry risks. Examples include the seller refusing to transfer the shares at the future date, even if the seller owns them, the seller going bankrupt with creditors claiming the shares, or the seller committing the same shares to multiple parties. Due diligence is essential. Seek legal and investment advice as needed.
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