
Locus Biosciences is a clinical-stage biotechnology company developing engineered bacteriophage therapies, called crPhage products, that combine the natural bacteria-killing power of phage with the precision DNA-targeting of CRISPR-Cas3 to selectively eliminate pathogenic bacteria while preserving the beneficial microbiome. The company's lead program, LBP-EC01, is being developed for complicated urinary tract infections caused by E. coli and is in the registrational Phase 2/3 ELIMINATE trial supported by BARDA. Locus was spun out of North Carolina State University and Duke University in 2015 and has built an integrated platform combining CRISPR-Cas3 payloads, AI-driven phage prediction, synthetic biology, and automated screening to develop precision antibacterials targeting antibiotic-resistant infections.
Company data and valuation marks are estimates and may be incomplete, stale, erroneous, or revised.
Founded
2015
Employees
50–100
Total Funding
$77.9M
4 rounds
Total raised $77.9M across 4 rounds
Funding data and valuation marks are estimates and may be incomplete, stale, erroneous, or revised.
Last updated 06-25-2026
Latest Round
Type
Non-dilutive (BARDA Phase 2)
Date
January 23, 2024
Amount
$23.9M
Valuation
—
Lead Investors
| Date | Round | Amount Raised | Valuation | Lead Investors |
|---|---|---|---|---|
| January 23, 2024 | Non-dilutive (BARDA Phase 2) | $23.9M | — | BARDA |
| May 2022 | Series B | $35M | — | Viking Global Investors |
| October 2019 | Series A (extension/A2) | Not disclosed | — | Illumina Ventures |
Paul Garofolo
Co-Founder, Chief Executive Officer & Chairman of the Board
Joseph Nixon
Chief Financial Officer
Tamara T. Monesmith
Senior Vice President, Chemistry, Manufacturing & Controls
Jamie Kime
Vice President, Clinical Operations
Rodolphe Barrangou
Co-Founder & Scientific Advisor
Charles Gersbach
Co-Founder & Scientific Advisor
Chase Beisel
Co-Founder & Scientific Advisor
Dave Ousterout
Co-Founder
Competitor list is illustrative and may be incomplete, stale, or erroneous.
Armata Pharmaceuticals
Clinical-stage developer of natural and engineered bacteriophage therapeutics for drug-resistant bacterial infections (Pseudomonas, Staphylococcus).
BiomX
Clinical-stage developer of natural and engineered phage cocktails for chronic infections including cystic fibrosis and diabetic foot osteomyelitis.
SNIPR Biome
Danish biotech developing CRISPR-based precision microbiome therapeutics that selectively eradicate target bacteria.
Eligo Bioscience
French biotech developing CRISPR-armed phage capsid delivery vehicles to edit or eliminate microbiome bacteria with sequence specificity.
PHAXIAM Therapeutics
France-based clinical-stage company developing natural bacteriophage therapeutics for antibiotic-resistant bacterial infections.
Adaptive Phage Therapeutics
Developer of a curated phage bank and matching platform (PhageBank) for personalized phage therapy against multidrug-resistant infections.
No. Locus Biosciences is a private company and does not have a public stock ticker or trade on a public stock exchange. Its shares are generally held by founders, employees, investors, and other private shareholders. Buyers and sellers may be able to transact in Locus Biosciences shares through private secondary transactions, but any transaction depends on share availability, buyer and seller agreement, transfer restrictions, company approval rights, and any applicable right of first refusal. There is no guarantee that Locus Biosciences will complete an IPO or other liquidity event.
Yes, it is sometimes possible to buy Locus Biosciences shares pre-IPO through private secondary transactions. This depends on finding a willing seller, company approval, and satisfying any transfer restrictions or rights of first refusal.
Buyers interested in buying Locus Biosciences shares on the secondary market typically do so through SetterVC and other secondary-market platforms, subject to eligibility requirements, share availability, transfer restrictions, and issuer approval. Buyers may need to satisfy sophistication, accreditation, institutional, platform, regulatory, or other eligibility requirements before participating. Once eligible, buyers may be able to view listings, make bids, and work with a licensed broker through the transaction process. Buyers should ensure they have appropriate legal and financial advisors guiding them before completing any transaction.
Locus Biosciences's latest disclosed funding round was a Non-dilutive (BARDA Phase 2) round in January 23, 2024. The round raised approximately $23.9M, with BARDA listed as disclosed lead or major investors. Primary funding rounds are different from secondary transactions: in a primary round, capital goes to the company, while in a secondary transaction, investors buy existing shares from current shareholders. Funding-round data reflects publicly reported or collected information and may be incomplete.
Locus Biosciences has raised approximately $77.9M in disclosed funding across 4 rounds. These figures reflect primary capital raised by the company and do not include every possible secondary transaction, undisclosed round, debt facility, or private transfer. Reported funding totals can change as new rounds are announced or older round details are corrected. Eligible users can use SetterVC to track Locus Biosciences's funding history alongside private-market activity where available.
Locus Biosciences's disclosed investors include av.co, tencent.com, Viking Global Investors, Johnson & Johnson Innovation - JJDC and innovation-discovery.com. Investor lists are based on public reporting, company announcements, and collected funding-round data, and may be incomplete. Participation in a prior funding round does not mean those investors are currently buying or selling shares. On SetterVC, eligible users can review Locus Biosciences's funding history, valuation history, and private-market activity alongside other venture-backed companies.
Locus Biosciences's most-cited competitors include Armata Pharmaceuticals, BiomX, SNIPR Biome, Eligo Bioscience, PHAXIAM Therapeutics and Adaptive Phage Therapeutics. Investors often compare these companies by sector, product focus, valuation, funding raised, growth signals, investor base, and private-market activity.
Secondary-market demand for Locus Biosciences shares can be affected by company performance, revenue growth, profitability, funding history, valuation, investor interest, sector momentum, public-market conditions, expected timing of a liquidity event, and the availability of shares for sale. Demand can also be affected by transfer restrictions, company approval rights, right of first refusal processes, limited information, and the price expectations of buyers and sellers. Strong demand does not guarantee strong pricing, liquidity, or investment returns. Weak demand does not necessarily reflect the company's long-term prospects. Demand signals should not be treated as a recommendation or prediction of investment performance. Buyers and sellers should treat demand signals as informational and conduct their own diligence before transacting.
Sellers often rely on intermediaries and platforms, such as SetterVC and other secondary-market platforms, to identify potential buyers. The exact process varies by company and transaction, but sellers often begin by confirming their ownership, desired price, transferability, and any company approval or notice requirements. If the seller agrees with a buyer on acceptable price and terms, the company may need to be notified through a share transfer notice or similar process. If a right of first refusal, company approval right, or other transfer restriction applies, the seller may need to wait until that process is completed. The parties may then execute a purchase and sale agreement, complete required transfer documentation, and close if all required conditions are satisfied. Sellers should always seek proper legal and financial advice before completing the transaction.
Yes, current and former Locus Biosciences employees, early investors, and other existing shareholders may be able to sell vested shares before an IPO through a private secondary sale. This is not automatic; it depends on whether the shareholder has transferable shares, whether there is buyer demand, and whether the company's governing documents permit the transfer. Many companies require prior notice, company approval, or a right of first refusal before shares can be sold. Sellers should also seek proper legal and financial advice before proceeding.
A Locus Biosciences secondary transaction usually involves an existing shareholder selling shares to a buyer before a public listing. The buyer and seller typically agree on price, number of shares, share class, and closing conditions. The seller may then need to notify Locus Biosciences through a share transfer notice or similar process. If Locus Biosciences or existing investors have approval rights, transfer restrictions, or a right of first refusal, those steps may need to be completed before the transfer can close. The parties typically enter into a purchase and sale agreement, complete any required transfer documentation, and close only if the necessary conditions are satisfied. Timing and certainty can vary by company and transaction.
In most private secondary transactions, parties commonly use a purchase and sale agreement that outlines price, terms, and conditions. They may also use share transfer documentation, often a stock transfer notice, share transfer notice, transfer instruction, or similar document, along with any required company approval or right of first refusal materials. Proof of ownership, such as a cap table entry, share certificate, brokerage statement, issuer confirmation, or administrator confirmation, may also be important. Buyers often request recent company financials, but private companies may limit disclosure. Since every deal varies, buyers and sellers should consult legal and financial advisors to understand which documents are needed.
Buying Locus Biosciences shares pre-IPO is risky. Shares are illiquid, no IPO or liquidity event is guaranteed, valuations can change, transfers may require company approval, and private companies may provide limited financial disclosure. Be prepared for total loss. SetterVC and Setter Capital do not provide due diligence, legal, tax, accounting, valuation, or investment advice. Buyers must conduct their own due diligence, verify information, and seek independent legal and investment advice before proceeding.
Private secondary shares are typically illiquid. Unlike public stocks, there is no active public market, so selling them can be difficult and time-consuming. Sales depend on finding a willing buyer and often require company approval. Investors should be prepared to hold the shares for an extended period, with no guarantee of a future sale. Always assess your need for liquidity before investing.
SetterVC and Setter Capital do not provide due diligence, legal, tax, accounting, valuation, or investment advice. Buyers must conduct their own due diligence, including verifying ownership, transferability, legal structure, company approval, and assessing the company's prospects. SetterVC and Setter Capital do not provide advice on whether an investment is good, what price to pay, or what the best bid or ask is. SetterVC and Setter Capital may share documents in some circumstances, but it does not guarantee their accuracy or completeness. Due diligence is essential. Seek legal and investment advice as needed.
Before buying Locus Biosciences shares, a buyer should try to review the share class, price per share, implied valuation, transfer restrictions, ROFR process, company approval rights, seller ownership evidence, recent financing or tender-offer information, available financial information, information rights, resale restrictions, tax considerations, and expected liquidity paths. Not all information may be available for a private company. Buyers should confirm available diligence, process details, and information needs with their own legal, tax, and investment advisers.
SPVs carry risks. Examples include the need to confirm the company allows SPV-based transfers, verify that the SPV truly owns the shares or interests it claims to own, and ensure it has not sold more interests than it holds. Due diligence is essential. Seek legal and investment advice as needed.
Forward contracts carry risks. Examples include the seller refusing to transfer the shares at the future date, even if the seller owns them, the seller going bankrupt with creditors claiming the shares, or the seller committing the same shares to multiple parties. Due diligence is essential. Seek legal and investment advice as needed.
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